2-[(5-anilino-1,3,4-thiadiazol-2-yl)thio]ethanol

Description

2-[(5-anilino-1,3,4-thiadiazol-2-yl)thio]ethanol : no description available [CHeBI]

Cross-References

ID Source	ID
PubMed CID	3242010
CHEMBL ID	1348405
CHEBI ID	109296

Synonyms (15)

Synonym
EU-0015908
MLS000090273
smr000024883
2-[(5-anilino-1,3,4-thiadiazol-2-yl)thio]ethanol
CHEMDIV2_001597
CHEBI:109296
HMS1373I13
2-[(5-anilino-1,3,4-thiadiazol-2-yl)sulfanyl]ethanol
HMS2171N11
AB00414798-08
HMS3314A22
CHEMBL1348405
AKOS034534102
Q27188378
Z71197637

Drug Classes (1)

Class	Description
aryl sulfide	Any organic sulfide in which the sulfur is attached to at least one aromatic group.

Protein Targets (10)

Potency Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)
Luciferase	Photinus pyralis (common eastern firefly)	Potency	30.1313	AID588342
ATAD5 protein, partial	Homo sapiens (human)	Potency	18.3564	AID504467
aldehyde dehydrogenase 1 family, member A1	Homo sapiens (human)	Potency	28.1838	AID1030
nonstructural protein 1	Influenza A virus (A/WSN/1933(H1N1))	Potency	19.9526	AID2326
P53	Homo sapiens (human)	Potency	50.1187	AID504706
NPC intracellular cholesterol transporter 1 precursor	Homo sapiens (human)	Potency	5.6234	AID485313
cellular tumor antigen p53 isoform a	Homo sapiens (human)	Potency	6.3096	AID902
chromobox protein homolog 1	Homo sapiens (human)	Potency	89.1251	AID540317
nuclear factor erythroid 2-related factor 2 isoform 2	Homo sapiens (human)	Potency	3.2643	AID504444
survival motor neuron protein isoform d	Homo sapiens (human)	Potency	0.0316	AID1458

Bioassays (7)

Assay ID	Title	Year	Journal	Article
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13ISSN: 1934-9300	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 ISSN: 1552-4922	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1 ISSN: 1557-8127	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13ISSN: 1934-9300	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 ISSN: 1552-4922	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1 ISSN: 1557-8127	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID651635	Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression	2022	The Journal of biological chemistry, 08, Volume: 298, Issue:8 ISSN: 1083-351X
AID504810	Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign	2010	Endocrinology, Jul, Volume: 151, Issue:7 ISSN: 1945-7170	A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID504812	Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign	2010	Endocrinology, Jul, Volume: 151, Issue:7 ISSN: 1945-7170	A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID1745845	Primary qHTS for Inhibitors of ATXN expression	2022	The Journal of biological chemistry, 08, Volume: 298, Issue:8 ISSN: 1083-351X
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13ISSN: 1934-9300	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 ISSN: 1552-4922	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1 ISSN: 1557-8127	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.

Research

Studies (5)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (20.00)	29.6817
2010's	3 (60.00)	24.3611
2020's	1 (20.00)	2.80

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	5 (100.00%)	84.16%

Substance	Classes	Roles	Relationship Strength
albendazole	aryl sulfide; benzimidazoles; benzimidazolylcarbamate fungicide; carbamate ester	anthelminthic drug; microtubule-destabilising agent; tubulin modulator	low
azathioprine	aryl sulfide; C-nitro compound; imidazoles; thiopurine	antimetabolite; antineoplastic agent; carcinogenic agent; DNA synthesis inhibitor; hepatotoxic agent; immunosuppressive agent; prodrug	low
bithionol	aryl sulfide; bridged diphenyl antifungal drug; bridged diphenyl fungicide; dichlorobenzene; organochlorine pesticide; polyphenol	antifungal agrochemical; antiplatyhelmintic drug	low
fenbendazole	aryl sulfide; benzimidazoles; carbamate ester	antinematodal drug	low
methiothepin	aryl sulfide; dibenzothiepine; N-alkylpiperazine; tertiary amino compound	antipsychotic agent; dopaminergic antagonist; geroprotector; serotonergic antagonist	low
1-(ethoxymethyl)-5-isopropyl-6-(phenylsulfanyl)uracil	aryl sulfide; pyrimidone		low
2,3-bis[amino-[(2-aminophenyl)thio]methylidene]butanedinitrile	aryl sulfide		low
pirinixic acid	aryl sulfide; organochlorine compound; pyrimidines		low
fentichlor	aryl sulfide; bridged diphenyl antifungal drug; monochlorobenzenes; polyphenol	antiinfective agent; drug allergen	low
methylphenylsulfide	aryl sulfide; benzenes		low
diphenyl sulfide	aryl sulfide		low
methiocarb	aryl sulfide; carbamate ester; methyl sulfide	acaricide; agrochemical; avicide; EC 3.1.1.7 (acetylcholinesterase) inhibitor; environmental contaminant; insecticide; molluscicide; xenobiotic	low
pipazethate	aryl sulfide		low
butoconazole nitrate	aryl sulfide; conazole antifungal drug; imidazole antifungal drug; imidazoles; organic nitrate salt		low
butoconazole	aryl sulfide; conazole antifungal drug; dichlorobenzene; imidazole antifungal drug; imidazoles; monochlorobenzenes		low
fenticonazole	aryl sulfide; dichlorobenzene; ether; imidazoles		low
nelfinavir	aryl sulfide; benzamides; organic heterobicyclic compound; phenols; secondary alcohol; tertiary amino compound	antineoplastic agent; HIV protease inhibitor	low
1-((2-hydroxyethoxy)methyl)-6-(phenylthio)thymine	aryl sulfide; primary alcohol; pyrimidone	antiviral drug; HIV-1 reverse transcriptase inhibitor	low
anpirtoline	aryl sulfide		low
azintamid	aryl sulfide		low
tiazuril	aryl sulfide		low
g 25671	aryl sulfide		low
irgarol 1051	aryl sulfide; cyclopropanes; diamino-1,3,5-triazine	antifouling biocide; environmental contaminant; xenobiotic	low
8-((4-chlorophenyl)thio)cyclic-3',5'-amp	3',5'-cyclic purine nucleotide; adenyl ribonucleotide; aryl sulfide; organochlorine compound	protein kinase agonist	low
zofenopril	aryl sulfide; L-proline derivative; N-acyl-L-amino acid; thioester	anticonvulsant; apoptosis inhibitor; cardioprotective agent; EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor; prodrug; vasodilator agent	low
bnps-skatole	aryl sulfide; bromoindole; C-nitro compound	reagent	low
5-(Ethylthio)-1,3,4-thiadiazol-2-amine	aryl sulfide		low
2-(s-glutathionyl)hydroquinone	aryl sulfide; glutathione conjugate; hydroquinones	human xenobiotic metabolite; nephrotoxic agent	low
2-s-cysteinyldopa	amino dicarboxylic acid; aryl sulfide; catechols; diamine; L-tyrosine derivative; S-conjugate; S-organyl-L-cysteine	human urinary metabolite	low
2-methyl-3-(phenylthio)pyrazine	aryl sulfide		low
3-(prop-2-enylthio)-5-thiophen-2-yl-1H-1,2,4-triazole	aryl sulfide		low
5-[(4-chlorophenyl)methylthio]-1,3,4-thiadiazol-2-amine	aryl sulfide		low
pd 173955	aryl sulfide; dichlorobenzene; methyl sulfide; pyridopyrimidine	tyrosine kinase inhibitor	low
6-methyl-2-(methylthio)-N-phenyl-5-prop-2-enyl-4-pyrimidinamine	aryl sulfide		low
4-(2-pyridinylthio)benzofuro[3,2-d]pyrimidine	aryl sulfide		low
2-[[3-cyano-6-(2-furanyl)-4-(trifluoromethyl)-2-pyridinyl]thio]propanoic acid ethyl ester	aryl sulfide		low
N,N-di(propan-2-yl)-2-[(1-propyl-5-tetrazolyl)thio]acetamide	aryl sulfide		low
3-[(4,6-dimethyl-2-pyrimidinyl)thio]-N,N-dimethylpropanamide	aryl sulfide		low
2-[(2,5-dimethylphenyl)methylthio]-5-(3-pyridinyl)-1,3,4-oxadiazole	aryl sulfide		low
2-[[5-(2-furanyl)-4-(2-furanylmethyl)-1,2,4-triazol-3-yl]thio]-1-(4-morpholinyl)ethanone	aryl sulfide		low
N,N-diethyl-2-[(3-thiophen-2-yl-7-isothiazolo[4,5-d]pyrimidinyl)thio]acetamide	aryl sulfide		low
2-[[3-cyano-6-cyclopropyl-4-(trifluoromethyl)-2-pyridinyl]thio]acetic acid methyl ester	aryl sulfide		low
4-[(3-cyano-4,6-dimethyl-2-pyridinyl)thio]-3-oxobutanoic acid propan-2-yl ester	aryl sulfide; isopropyl ester		low
2-[[5-[[2-(3-chloroanilino)-4-thiazolyl]methyl]-4-(3-methoxypropyl)-1,2,4-triazol-3-yl]thio]acetic acid methyl ester	aryl sulfide		low
2-[(6-amino-3,5-dicyano-4-thiophen-2-yl-2-pyridinyl)thio]-N-(2-phenylethyl)acetamide	aryl sulfide		low
6-tert-butyl-3-cyclohexyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine	aryl sulfide		low
2-[(3-cyano-6-cyclopropyl-4-thiophen-2-yl-2-pyridinyl)thio]acetamide	aryl sulfide		low
5-[2-[(4-chlorophenyl)thio]-1-oxoethyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic acid methyl ester	aryl sulfide		low
4-(benzylsulfanyl)thieno[2,3-d]pyrimidine	aryl sulfide; benzenes; thienopyrimidine		low
2-(Phenylthio)nicotinic acid	aryl sulfide		low
5-[(2-Chloro-6-fluorobenzyl)thio]-1,3,4-thiadiazol-2-amine	aryl sulfide		low
2-[(2-fluorophenyl)methylthio]-5-(4-methylphenyl)-1,3,4-oxadiazole	aryl sulfide		low
2-[(4-fluorophenyl)methylthio]-5-(2-methylphenyl)-1,3,4-oxadiazole	aryl sulfide		low
2-[(6-amino-3,5-dicyano-2-pyridinyl)thio]acetic acid ethyl ester	aryl sulfide		low
2-methyl-5-[(2-methyl-4-quinolinyl)thio]-1,3,4-thiadiazole	aryl sulfide		low
2-[(4-bromophenyl)methylthio]-5-(3-pyridinyl)-1,3,4-oxadiazole	aryl sulfide		low
GS4012 free base	aryl sulfide; monomethoxybenzene; pyridines	VEGF activator	low
2-(phenylmethylthio)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazole	aryl sulfide		low
3-(2-methylpropylthio)-1H-1,2,4-triazol-5-amine	aryl sulfide		low
8-[(2-methyl-5-nitro-1,2,4-triazol-3-yl)thio]quinoline	aryl sulfide		low
2-[(3-fluorophenyl)methylthio]pyrimidine-4,6-diamine	aryl sulfide		low
2-(4-chlorophenyl)-4-(ethylthio)-6-(1-pyrrolidinyl)pyrimidine	aryl sulfide		low
2-[(2-chlorophenyl)methylthio]-6,7-dihydro-5H-pyrrolo[1,2-a]imidazole	aryl sulfide		low
N-[(2-methylphenyl)methyl]-2-[(4-methylphenyl)thio]acetamide	aryl sulfide		low
N,N-dimethyl-3-[(4-methylphenyl)thio]propanamide	aryl sulfide		low
3-[(2-chloro-6-fluorophenyl)methylthio]-4-ethyl-5-(2-furanyl)-1,2,4-triazole	aryl sulfide		low
3-cyclohexyl-5-(phenylmethylthio)-1,2,4-triazol-4-amine	aryl sulfide		low
N,N-dimethyl-2-[(2-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)thio]ethanamine	aryl sulfide		low
3-chloro-4-[(1-ethyl-2-benzimidazolyl)thio]aniline	aryl sulfide		low
2-[[3-cyano-6-(2-furanyl)-4-(trifluoromethyl)-2-pyridinyl]thio]-N,N-diethylacetamide	aryl sulfide		low
5-[2-[(4-chlorophenyl)thio]-1-oxoethyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester	aryl sulfide		low
2-[(4-chlorophenyl)thio]-N-(5-oxo-1-phenyl-4H-pyrazol-3-yl)acetamide	aryl sulfide		low
N-[3-(1,3-benzothiazol-2-ylthio)-4-hydroxyphenyl]-4-chlorobenzenesulfonamide	aryl sulfide		low
3-[5-[(4-chlorophenyl)methylthio]-1,3,4-oxadiazol-2-yl]-1-(phenylmethyl)-2-pyridinone	aryl sulfide		low
4-[(3-methylphenyl)thio]-2-phenyl-5-pyrimidinecarboxylic acid	aryl sulfide		low
3-phenyl-5-[(phenylthio)methyl]isoxazole	aryl sulfide		low
3-(4-chlorophenyl)-5-[(phenylthio)methyl]isoxazole	aryl sulfide		low
3-[4-ethyl-5-[(4-methylphenyl)methylthio]-1,2,4-triazol-3-yl]-1-phenyl-4-pyridazinone	aryl sulfide		low
5-[3-[(4-methylphenyl)methoxy]-2-thiophenyl]-3-(methylthio)-1H-1,2,4-triazole	aryl sulfide		low
5-methoxy-4-[(2-methoxyphenyl)thio]-2-phenylpyrimidine	aryl sulfide		low
3-[(4-ethylsulfonyl-2-nitrophenyl)thio]-4-methyl-1,2,4-triazole	aryl sulfide		low
1-[[1-oxo-2-[[5-(phenylmethylthio)-1,3,4-thiadiazol-2-yl]thio]ethyl]amino]-3-phenylthiourea	aryl sulfide		low
8-(dimethylamino)-3,4-dihydro-2H-pyrimido[2,1-b][1,3]thiazin-6-one	aryl sulfide		low
1-[[4-[(3,4-dichlorophenyl)thio]-3-pyridinyl]sulfonyl]-3-propylurea	aryl sulfide		low
N,N-dimethyl-3-[(2-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)thio]-1-propanamine	aryl sulfide		low
2-tert-butyl-4-[(4-chlorophenyl)thio]-5-methyl-1H-pyrazol-3-one	aryl sulfide		low
benzoic acid [2-oxo-2-[2-(phenylthio)anilino]ethyl] ester	aryl sulfide		low
7-[[[5-(2,4-dimethylanilino)-1,3,4-thiadiazol-2-yl]thio]methyl]-5-thiazolo[3,2-a]pyrimidinone	aryl sulfide		low
N-phenyl-5-(propan-2-ylthio)-1,3,4-thiadiazol-2-amine	aryl sulfide		low
2-[(6-amino-3,5-dicyano-4-thiophen-2-yl-2-pyridinyl)thio]acetic acid ethyl ester	aryl sulfide		low
5-methyl-3-[3-[(5-methyl-1H-1,2,4-triazol-3-yl)thio]propylthio]-1H-1,2,4-triazole	aryl sulfide		low
N-[2-[(2-methylphenyl)methylthio]ethyl]-3-[(4-methylphenyl)thio]propanamide	aryl sulfide		low
1,3-dimethyl-5-[[5-(phenylthio)-2-furanyl]methylidene]-1,3-diazinane-2,4,6-trione	aryl sulfide		low
2-(1,3-benzothiazol-2-yl)-4-[(4-fluorophenyl)thio]-5-methyl-3-pyrazolamine	aryl sulfide		low
2-(4,6-dimethyl-2-pyrimidinyl)-4-[(4-fluorophenyl)thio]-5-methyl-3-pyrazolamine	aryl sulfide		low
2-[[5-(2-fluoroanilino)-1,3,4-thiadiazol-2-yl]thio]-N-(2-furanylmethyl)acetamide	aryl sulfide		low
1-(2-furanyl)-2-(1H-1,2,4-triazol-5-ylthio)ethanone	aryl sulfide		low
4-[(1-methyl-5-tetrazolyl)thio]-5-phenylthieno[2,3-d]pyrimidine	aryl sulfide; thienopyrimidine		low
2-chloro-N-[4-[(3,4-dimethylphenyl)thio]phenyl]acetamide	aryl sulfide		low
2-[(3,4-dimethylphenyl)thio]-3-pyridinecarboxylic acid	aryl sulfide		low
N-[6-amino-2,4-dioxo-1-(phenylmethyl)-5-pyrimidinyl]-2-[(5-amino-1,3,4-thiadiazol-2-yl)thio]-N-methylacetamide	aryl sulfide		low
2-[[5-(2-furanyl)-1,3,4-oxadiazol-2-yl]thio]-1-(1H-pyrrol-2-yl)ethanone	aryl sulfide		low
N-tert-butyl-2-[[4-(4-fluorophenyl)-2-thiazolyl]thio]acetamide	aryl sulfide		low
2-(4-chlorophenyl)-5-[[(4-methyl-2-thiazolyl)thio]methyl]-1,3,4-oxadiazole	aryl sulfide		low
s-phenyl-n-acetylcysteine	aryl sulfide; S-substituted N-acetyl-L-cysteine	biomarker; human urinary metabolite	low
4-amino-2-(4-chlorophenyl)-6-(methylthio)pyrimidine-5-carbonitrile	aryl sulfide		low
[3,5-Bis(methylsulfanyl)-4-isothiazolyl]methanol	aryl sulfide		low
bi-78d3	aryl sulfide		low
2-[(4-chlorophenyl)thio]-1-methyl-3-indolecarboxaldehyde	aryl sulfide		low
1-[(3-chlorophenyl)methyl]-3-[5-(methylthio)-1,3,4-oxadiazol-2-yl]-2-pyridinone	aryl sulfide		low
2-[(2-methylphenyl)methylthio]-5-pyridin-4-yl-1,3,4-oxadiazole	aryl sulfide		low
3-[(2-sulfanylidene-3H-1,3,4-thiadiazol-5-yl)thio]propanoic acid ethyl ester	aryl sulfide		low
2-[(2-sulfanylidene-3H-1,3,4-thiadiazol-5-yl)thio]butanedioic acid	aryl sulfide		low
N-{2-[(4-amino-5-cyano-2-pyrimidinyl)sulfanyl]acetyl}-N'-phenylurea	aryl sulfide		low
2-[5-[(3-chlorophenyl)thio]-2-thiophenyl]pyridine	aryl sulfide		low
2-{5-[2-(Phenylthio)acetyl]-2-thienyl}acetic acid	aryl sulfide		low
2-[5-[2-[(4-methylphenyl)thio]-1-oxoethyl]-2-thiophenyl]acetic acid	aryl sulfide		low
2-[[2-methyl-5-nitro-3-(phenylmethyl)-4-imidazolyl]thio]-6-nitro-1H-benzimidazole	aryl sulfide		low
1-(2-furanyl)-3-(phenylthio)-3-thiophen-2-yl-1-propanone	aryl sulfide		low
1-(2-furanyl)-2-[(1-methyl-5-tetrazolyl)thio]ethanone	aryl sulfide		low
N-(1-adamantyl)-2-[(1-methyl-2-imidazolyl)thio]acetamide	aryl sulfide		low
u 0126	aryl sulfide; dinitrile; enamine; substituted aniline	antineoplastic agent; antioxidant; apoptosis inducer; EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor; osteogenesis regulator; vasoconstrictor agent	low
zofenoprilate	aryl sulfide; L-proline derivative; N-acyl-L-amino acid; thiol	anticonvulsant; apoptosis inhibitor; cardioprotective agent; drug metabolite; EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor; vasodilator agent	low
vx-745	aryl sulfide; dichlorobenzene; difluorobenzene; pyrimidopyridazine	anti-inflammatory drug; apoptosis inducer; EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor	low
N-methyl-2-[[3-[2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]thio]benzamide	aryl sulfide		low
2,2-dimethyl-N-[2,2,2-trichloro-1-(2-pyrimidinylthio)ethyl]propanamide	aryl sulfide		low
5-methyl-4-[(3-methyl-5-oxo-1,2-dihydropyrazol-4-yl)-[4-(methylthio)phenyl]methyl]-1,2-dihydropyrazol-3-one	aryl sulfide		low
1-(4-amino-1,2,5-oxadiazol-3-yl)-5-[(2-pyridinylthio)methyl]-4-triazolecarboxylic acid propan-2-yl ester	aryl sulfide; azole; isopropyl ester; oxadiazole; pyridines		low
2-[[4-cyano-3-[(2-methoxy-2-oxoethyl)thio]-5-isothiazolyl]thio]acetic acid ethenyl ester	aryl sulfide		low
2-amino-4-[5-methyl-2-(methylthio)-3-thiophenyl]-5-oxo-1-(3-pyridinyl)-4,6,7,8-tetrahydroquinoline-3-carbonitrile	aryl sulfide		low
3-nitro-4-[[4-(2-oxolanylmethyl)-5-thiophen-2-yl-1,2,4-triazol-3-yl]thio]benzamide	aryl sulfide		low
1-(4-methoxyphenyl)-4-[(4-methylphenyl)thio]-6-oxo-3-pyridazinecarboxylic acid methyl ester	aryl sulfide		low
3-(phenylthio)-1-(1-pyrrolidinyl)-1-propanone	aryl sulfide		low
gw 7647	aryl sulfide; monocarboxylic acid; ureas	PPARalpha agonist	low
2-[(4-methyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)thio]acetic acid ethyl ester	aryl sulfide		low
4-[[7-methyl-4-(phenylthio)-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-2-yl]methyl]morpholine	aryl sulfide		low
2-[[4-(4-chlorophenyl)-5-sulfanylidene-1,3,4-thiadiazol-2-yl]thio]-N-(1,1-dioxo-3-thiolanyl)-N-(2-methylpropyl)acetamide	aryl sulfide		low
l 663536	aryl sulfide; indoles; monocarboxylic acid; monochlorobenzenes	antineoplastic agent; EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor; leukotriene antagonist	low
2-[(2-sulfanylidene-3H-1,3,4-thiadiazol-5-yl)thio]propanoic acid methyl ester	aryl sulfide		low
4-[(3-cyano-6,7-dihydro-5H-cyclopenta[b]pyridin-2-yl)thio]-3-oxobutanoic acid ethyl ester	aryl sulfide		low
5-[[(4-chlorophenyl)thio]methyl]-2-methyl-1H-pyrazol-3-one	aryl sulfide		low
1-(1-azepanyl)-2-[(5-methyl-4-nitro-1H-pyrazol-3-yl)thio]ethanone	aryl sulfide		low
1-(1-adamantyl)-2-[(1-oxido-2-pyridin-1-iumyl)thio]ethanone	aryl sulfide		low
2-[(2-nitro-3-pyridinyl)oxy]-N-[2-(phenylthio)phenyl]acetamide	aryl sulfide		low
3-amino-4-[(4-chlorophenyl)thio]benzoic acid methyl ester	aryl sulfide		low
5-[(3-nitro-2-pyridinyl)thio]-N-prop-2-enyl-1,3,4-thiadiazol-2-amine	aryl sulfide		low
3-(prop-2-enylthio)-[1,2,4]triazino[5,6-d][3,1]benzoxazepine	aryl sulfide		low
sulindac sulfide	aryl sulfide; monocarboxylic acid; organofluorine compound	antineoplastic agent; apoptosis inducer; non-steroidal anti-inflammatory drug	low
cinanserin	aryl sulfide; cinnamamides; secondary carboxamide; tertiary amino compound	anticoronaviral agent; antiviral agent; EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor	low
5-[(2-chlorophenyl)thio]-3-(4-methylphenyl)-1,2,4-triazine-6-carboxylic acid ethyl ester	aryl sulfide		low
3-(2-oxolanylmethylthio)-5,6-diphenyl-1,2,4-triazine	aryl sulfide		low
axitinib	aryl sulfide; benzamides; indazoles; pyridines	antineoplastic agent; tyrosine kinase inhibitor; vascular endothelial growth factor receptor antagonist	low
2-[[4-methyl-5-(2-phenylethyl)-1,2,4-triazol-3-yl]thio]acetic acid methyl ester	aryl sulfide		low
2-[(3-iodophenyl)methylthio]-5-pyridin-4-yl-1,3,4-oxadiazole	aryl sulfide		low
n,n'-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine	aryl sulfide		low
7-[(4-chlorophenyl)methylthio]-3-methyl-[1,3,4]thiadiazolo[2,3-c][1,2,4]triazin-4-one	aryl sulfide		low
7-[(3-chlorophenyl)methylthio]-3-methyl-[1,3,4]thiadiazolo[2,3-c][1,2,4]triazin-4-one	aryl sulfide		low
3-methyl-7-[(3-methylphenyl)methylthio]-[1,3,4]thiadiazolo[2,3-c][1,2,4]triazin-4-one	aryl sulfide		low
3-(ethylthio)-6-(2-furanyl)pyridazine	aryl sulfide		low
3-[(3-fluorophenyl)methylthio]-6-(2-furanyl)pyridazine	aryl sulfide		low
3-[(4-bromophenyl)methylthio]-6-(2-furanyl)pyridazine	aryl sulfide		low
3-[(4-chlorophenyl)methylthio]-6-(2-furanyl)pyridazine	aryl sulfide		low
5-(4-chlorophenyl)-4-[(1-methyl-5-tetrazolyl)thio]thieno[2,3-d]pyrimidine	aryl sulfide; thienopyrimidine		low
gw 501516	1,3-thiazoles; aromatic ether; aryl sulfide; monocarboxylic acid; organofluorine compound	carcinogenic agent; PPARbeta/delta agonist	low
4-[(4-methylphenyl)thio]-2-thieno[2,3-c]pyridinecarboxamide	aryl sulfide		low
cangrelor	adenosine 5'-phosphate; aryl sulfide; nucleoside triphosphate analogue; organochlorine compound; organofluorine compound; secondary amino compound	P2Y12 receptor antagonist; platelet aggregation inhibitor	low
[2-[[2-[(dimethylamino)methyl]phenyl]thio]-5-iodophenyl]methanol	aryl sulfide		low
ticagrelor	aryl sulfide; hydroxyether; organofluorine compound; secondary amino compound; triazolopyrimidines	P2Y12 receptor antagonist; platelet aggregation inhibitor	low
vortioxetine	aryl sulfide; N-arylpiperazine	antidepressant; anxiolytic drug; serotonergic agonist; serotonergic antagonist	low
n,n-dimethyl-2-(2-amino-4-fluorophenylthio)benzylamine	aryl sulfide		low
abt-737	aromatic amine; aryl sulfide; biphenyls; C-nitro compound; monochlorobenzenes; N-arylpiperazine; N-sulfonylcarboxamide; secondary amino compound; tertiary amino compound	anti-allergic agent; anti-inflammatory agent; antineoplastic agent; apoptosis inducer; B-cell lymphoma 2 inhibitor	low
bay 60-6583	aminopyridine; aromatic ether; aryl sulfide; cyanopyridine; cyclopropanes; monocarboxylic acid amide	adenosine A2B receptor agonist; anti-inflammatory agent; cardioprotective agent	low
3-[(3-methylphenyl)methylthio]-6-thiophen-2-ylpyridazine	aryl sulfide		low
3-[[5-(4-ethylanilino)-1,3,4-thiadiazol-2-yl]thio]-2-oxolanone	aryl sulfide		low
3-(3-pyridinylmethylthio)-6-thiophen-2-ylpyridazine	aryl sulfide		low
sgx 523	aryl sulfide; biaryl; pyrazoles; quinolines; triazolopyridazine	c-Met tyrosine kinase inhibitor; nephrotoxic agent	low
navitoclax	aryl sulfide; monochlorobenzenes; morpholines; N-sulfonylcarboxamide; organofluorine compound; piperazines; secondary amino compound; sulfone; tertiary amino compound	antineoplastic agent; apoptosis inducer; B-cell lymphoma 2 inhibitor	low
5-(4-methoxyphenyl)-4-[(1-methyl-5-tetrazolyl)thio]thieno[2,3-d]pyrimidine	aryl sulfide; thienopyrimidine		low
5-(4-bromophenyl)-4-[(1-methyl-5-tetrazolyl)thio]thieno[2,3-d]pyrimidine	aryl sulfide; thienopyrimidine		low
5-(2-methoxyphenyl)-4-[(1-methyl-5-tetrazolyl)thio]thieno[2,3-d]pyrimidine	aryl sulfide; thienopyrimidine		low
5-(3-methoxyphenyl)-4-[(1-methyl-5-tetrazolyl)thio]thieno[2,3-d]pyrimidine	aryl sulfide; thienopyrimidine		low
5-(3-fluorophenyl)-4-[(1-methyl-5-tetrazolyl)thio]thieno[2,3-d]pyrimidine	aryl sulfide; thienopyrimidine		low
4-[(1-methyl-5-tetrazolyl)thio]-5-[2-(trifluoromethyl)phenyl]thieno[2,3-d]pyrimidine	aryl sulfide; thienopyrimidine		low
4-[(1-methyl-5-tetrazolyl)thio]-5-[3-(trifluoromethyl)phenyl]thieno[2,3-d]pyrimidine	aryl sulfide; thienopyrimidine		low
4-[(1-methyl-5-tetrazolyl)thio]-5-[4-(trifluoromethyl)phenyl]thieno[2,3-d]pyrimidine	aryl sulfide; thienopyrimidine		low
5-(2-bromophenyl)-4-[(1-methyl-5-tetrazolyl)thio]thieno[2,3-d]pyrimidine	aryl sulfide; thienopyrimidine		low
5-(3-bromophenyl)-4-[(1-methyl-5-tetrazolyl)thio]thieno[2,3-d]pyrimidine	aryl sulfide; thienopyrimidine		low
5-(2-chlorophenyl)-4-[(1-methyl-5-tetrazolyl)thio]thieno[2,3-d]pyrimidine	aryl sulfide; thienopyrimidine		low
4-[4-[(1-methyl-5-tetrazolyl)thio]-5-thieno[2,3-d]pyrimidinyl]benzonitrile	aryl sulfide; thienopyrimidine		low
4-[(1-methyl-5-tetrazolyl)thio]-5-(4-nitrophenyl)thieno[2,3-d]pyrimidine	aryl sulfide; thienopyrimidine		low
5-(1,3-benzodioxol-5-yl)-4-(1-methyltetrazol-5-yl)sulfanylthieno[2,3-d]pyrimidine	aryl sulfide; thienopyrimidine		low
4-[(1-methyl-5-tetrazolyl)thio]-5-(3-thiophenyl)thieno[2,3-d]pyrimidine	aryl sulfide; thienopyrimidine		low
5-(2-benzofuranyl)-4-[(1-methyl-5-tetrazolyl)thio]thieno[2,3-d]pyrimidine	aryl sulfide; thienopyrimidine		low
4-[(1-methyl-5-tetrazolyl)thio]-5-(1H-pyrrol-2-yl)thieno[2,3-d]pyrimidine	aryl sulfide; thienopyrimidine		low
5-(3-methylsulfonylphenyl)-4-[(1-methyl-5-tetrazolyl)thio]thieno[2,3-d]pyrimidine	aryl sulfide; thienopyrimidine		low
4-[(1-methyl-5-tetrazolyl)thio]-5-(1-naphthalenyl)thieno[2,3-d]pyrimidine	aryl sulfide; thienopyrimidine		low
5-bromo-4-[(1-methyl-5-tetrazolyl)thio]thieno[2,3-d]pyrimidine	aryl sulfide; thienopyrimidine		low
monepantel	(trifluoromethyl)benzenes; aromatic ether; aryl sulfide; nitrile; secondary carboxamide	anthelminthic drug; nematicide	low
lesinurad	aryl sulfide; cyclopropanes; monocarboxylic acid; naphthalenes; organobromine compound; triazoles	uricosuric drug	low
2-(methylthio)-6-(phenylmethyl)-1H-pyrimidin-4-one	aryl sulfide		low
2-[(4-chlorophenyl)methylthio]-1,5,6,7-tetrahydrocyclopenta[d]pyrimidin-4-one	aryl sulfide		low
2-[[2-[1-(2-methoxyethyl)-2,5-dimethyl-3-pyrrolyl]-2-oxoethyl]thio]-6-propyl-1H-pyrimidin-4-one	aryl sulfide		low
5-methyl-2-methylsulfanyl-6-propyl-1H-pyrimidin-4-one	aryl sulfide		low
8-((4-chlorophenyl)thio)cyclic-3',5'-gmp	3',5'-cyclic purine nucleotide; aryl sulfide; organochlorine compound; ribonucleotide	protein kinase agonist	low
febantel	aryl sulfide		low
2-(butylthio)-1,5,6,7-tetrahydrocyclopenta[d]pyrimidin-4-one	aryl sulfide		low
2-(2-phenylethylthio)-1,5,6,7-tetrahydrocyclopenta[d]pyrimidin-4-one	aryl sulfide		low

Condition	Indicated	Studies	First Year	Last Year	Average Age	Relationship Strength	Trials	pre-1990	1990's	2000's	2010's	post-2020
Inflammation	0	1	2010	2010	14.0	high	0	0	0	1	0	0
Innate Inflammatory Response	0	1	2010	2010	14.0	high	0	0	0	1	0	0

2-[(5-anilino-1,3,4-thiadiazol-2-yl)thio]ethanol

Description

Cross-References

Synonyms (15)

Drug Classes (1)

Protein Targets (10)

Potency Measurements

Bioassays (7)

Research

Studies (5)

Study Types

Related Drugs (207)

Drugs in this Class (207)

Related Conditions (2)